Current Studies

If you are interested in participating in a study, click here.

Brain Development and Environmental Factors Study

Principal Investigator:

Dr. Ellen Grant, MD

 

Co-Investigators:

Dr. Banu Ahtam, PhD

Dr. Borjan Gagoski, PhD

Research Assistants

Michaela Sisitsky

The purpose of this research is to study how brain development is affected by various environmental factors, such as language exposure, parental backgrounds, mother-child interactions, and socioeconomic status. The study consists of up to two visits, which occur prior to the participant turning 12 months old. MRI is used to take images of the brain and to study how it is developing at each visit throughout the study.

Intraventricular Hemorrhage (IVH)/Hydrocephalus Study 

Principal Investigator:

Dr. Pei-Yi Lin, PhD

Co-Investigators:

Dr. Ellen Grant, MD

Dr. Ben Warf, MD

Research Assistants:

Shoshana Freeman

The purpose of this research is to study baby brain health and long-term clinical and developmental outcomes. Prematurity can increase the risk of bleeding and/or swelling in the brain, which can potentially lead to long-term neurodevelopmental issues. This research study is also intended to test the clinical application of the FDNIRS-DCS device. This device uses non-invasive, optical light and allows us to measure cerebral blood flow in addition to oxygenation. Information from this research will help determine whether the monitor should be approved by the Food and Drug Administration and used routinely in the future.   In order to participate in this study, your baby must be admitted to intensive or intermediate care settings who are at risk for bleeding in the brain, dilation of ventricles in the brain, and/or increased head circumference.

For more information regarding this study, please contact the research team at (617)919-1309 .

Developing a Predictive Model of Fetal to Neonatal Brain Development in Congenital Heart Disease

Principal Investigator:

Dr. Kiho Im

 

Co-Investigators:

Research Assistants:

The purpose of this research study is to identify novel biomarkers that will detect abnormal brain development in second trimester fetuses with congenital heart disease (CHD) and will include variables that account for differences in fetal cardiovascular hemodynamics and deleterious variants in high brain-heart expressed genes and neuroresilence genes. It will also include modeling brain development from the second trimester fetus to neonate and predicting neonatal preoperative brain structure using deep learning techniques.

Placental Health Study

Principal Investigator:

Dr. Ellen Grant, MD

Co-Investigators:

Dr. Esra Abaci Turk, PhD

Dr. Jeffrey Stout, PhD

Dr. Borjan Gagoski, PhD

Research Assistants:

Elizabeth Holland

Our study team is interested in learning more about how the placenta functions during pregnancy and specifically, how oxygen and nutrients cross the placenta from mother to baby. The placenta is a unique organ that serves as a critical life support system for the developing fetus. Fetuses receiving less oxygen and nutrients are at risk of developing medical problems, including heart disease, growth problems, and brain injury. With MRI technologies that provide a better way to measure placental health, we might better distinguish unhealthy placentas from the healthy ones, and therefore help doctors make more informed decisions when managing high risk pregnancies and determining optimal delivery time.

 

For more information regarding this study, please contact the research team at 617-919-1306 or email elizabeth.holland@childrens.harvard.edu

TO CONTACT FNNDSC, PLEASE CALL OR EMAIL:

Richard Tammaro, Program Coordinator II

Tel: 857-218-5111

Email: richard.tammaro@childrens.harvard.edu

Fax: 617-730-4671

MAILING ADDRESS:

BCH Neonatal Imaging

BCH 3181

300 Longwood Avenue

Boston, MA 02115

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